Shimadzu Corporation Introduces the LCMS-8050 High-Sensitivity, Ultra-Fast Triple Quadrupole LC-MS/MS
8/23/2013
Shimadzu Corporation announces the release of the LCMS-8050, a triple quadrupole LC-MS/MS incorporating proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As the high-end model of its UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high sensitivity, high data quality, and the world's fastest data acquisition rates.
Background of Development
To remain competitive, laboratories using LC/MS/MS require higher throughput and reduced costs without sacrificing data quality. In September 2010, Shimadzu Corporation launched the LCMS-8030 triple quadrupole mass spectrometer, which offered the world's fastest scanning speed and polarity switching rate. In May 2012, Shimadzu launched the LCMS-8040, which delivered higher sensitivity while maintaining high-speed performance. Now, to meet the growing demand for trace-level quantitation in clinical research and other markets, Shimadzu launches the LCMS-8050, equipped with advanced high-speed performance and best-in-class sensitivity as the flagship product of the UFMS series.
(1) Unique Product Features
Delivering attogram-level sensitivity and possessing unsurpassed ruggedness, the LCMS-8050 achieves its improved sensitivity through the means of two important technologies:
Newly designed Heated ESI source improves desolvation and enhances ionization efficiency with the addition of a heated gas used in combination with the nebulizer gas.
UFsweeper®III collision cell enhances CID efficiency by optimizing the collision cell pressure.
One common design approach to increase sensitivity in mass spectrometers has been to incorporate a larger inlet to increase the number of ions introduced into the instrument. This approach necessitates the inclusion of a more powerful and more costly vacuum system. However, replacing vacuum pumps is inevitable and expensive, and a larger inlet leads to increased levels of instrument contamination. For these reasons, Shimadzu maintained a smaller inlet in the LCMS-8050. When combined with the new heated ESI source and UFsweeper III, Shimadzu has improved system performance and delivered a rugged LCMS system with a lower cost of ownership.
(2) Advanced UF Technologies
The newly engineered high voltage power supply enables a maximum scan rate of 30,000 u/sec and a 5 msec polarity switching time, making the LCMS-8050 combined with Nexera UHPLC the ideal platform for laboratory productivity. It is now possible to include 1000 events with up to 32 channels per event for a maximum of 32,000 MRMs per analysis.
Maximum Scanning Speed: 30,000 u/sec
Polarity Switching Rate: 5 msec
(3) User-friendly Operation and Easy Maintenance
Newly designed ion source
The new LCMS-8050 ion source is designed to allow easy changing from ESI to APCI or to dual ionization mode (DUIS). The source housing is cable-free and tubeless, integrating the gas and electrical connections for convenience and simplicity.
Seamless integration of HPLC and MS control software
LabSolutions LCMS Version 5.60 for LCMS-8030/8040/8050 provides intuitive, easy-to-use operation. It fully integrates operation of Shimadzu's LC product lines (Nexera and Prominence). An automated MRM optimization routine is provided, allowing unattended optimization of multiple compounds. Key MS voltages, critical to high-sensitivity analysis, are automatically adjusted and evaluated for each compound without user intervention.
Minimized instrument downtime and easy maintenance procedures
The desolvation capillary, which functions as the inlet to the mass spectrometer, can be quickly replaced without breaking vacuum, saving the user hours of recovery time. Probe maintenance is quick and easy, with readily accessible consumable components. Even more advanced maintenance is made simple; ion guides can be removed without tools and cleaned without extensive disassembly.
Shimadzu will show the LCMS-8050 at JASIS (Japan Analytical & Scientific Instruments Show) on September 4-6, 2013, in Makuhari Messe, Chiba, Japan. The LCMS-8050 will also be shown in Portugal on September 2-6, 2013 at the TIAFT conference (The International Association of Forensic Toxicologists), and on September 8-12, 2013 in Indianapolis Indiana, USA, at the ACS (American Chemical Society) exposition.
The Federal's pistol slid into its holster and his sabre flashed out. He threw its curved point up in a splendid salute. Ferry saluted with his straight blade. Then both swords rang back into their scabbards, and Jewett whirled away toward his column. For a moment we lingered, then faced to the left, trotted, galloped. Over the fence and into the road went he--went I. Down it, as we crossed, the blue column was just moving again. Then the woods on the south swallowed us up. "All right, sir." that before. Meanwhile the parallelism between Thought and Extension was not exhausted by the identification just analysed. Extension was not only a series of movements; it still remained an expression for co-existence and adjacency.412 Spinoza, therefore, felt himself obliged to supply Thought with a correspondingly continuous quality. It is here that his chief originality lies, here that he has been most closely followed by the philosophy of our own time. Mind, he declares, is an attribute everywhere accompanying matter, co-extensive and co-infinite with space. Our own animation is the sum or the resultant of an animation clinging to every particle that enters into the composition of our bodies. When our thoughts are affected by an external impulse, to suppose that this impulse proceeds from anything material is a delusion; it is produced by the mind belonging to the body which acts on our body; although in what sense this process is to be understood remains a mystery. Spinoza has clearly explained the doctrine of animal automatism, and shown it to be perfectly conceivable;569 but he has entirely omitted to explain how the parallel influence of one thought (or feeling) on another is to be understood; for although this too is spoken of as a causal relation, it seems to be quite different from the logical concatenation described as the infinite intellect of God; and to suppose that idea follows from idea like movement from movement would amount to a complete materialisation of mind; while our philosopher would certainly have repudiated Mr. Shadworth Hodgson’s theory, that states of consciousness are only connected through their extended substratum, as the segments of a mosaic picture are held together by the underlying surface of masonry. Nor can we admit that Spinoza entertained the theory, now so popular, according to which extension and consciousness are merely different aspects of a single reality. For this would imply that the substance which they manifest had an existence of its own apart from its attributes; whereas Spinoza makes it consist of the attributes, that is to say, identifies it with their totality. We are forced, then, to conclude that the proposition declaring thought and extension to be the same thing570 has no413 other meaning than that they are connected by the double analogy which we have endeavoured to explain. “Oh, he’s welcome to it,” Sandy cried. “I’ve turned over a new leaf!” “But—are they?” He pulled a wire out a trifle from the sheath. The sergeant spent more time upon the oaths with which he embellished the counter-question as to how he should know anything about it, than would have been consumed in a civil explanation. "Doctor, he can't die. He mustn't die," said Shorty in agony. "The regiment can't spare him. He's the best soldier in it, and he's my pardner." AND ENTERS UPON HIS PARENTAL RELATIONS TO LITTLE PETE SKIDMORE. "Holy smoke, look there," gasped Monty Scruggs, as a company of rebel cavalry came tearing over the hill in front, to the assistance of their comrades. "That's about it," answered Shorty disdainfully. "That's the way with all cavalry, dad-burn 'em. They're like a passel o' fice pups. They're all yelp and bark, and howl and showin' o' teeth. They're jest goin' to tear you to pieces. But when you pick up a stone or a club, or git ready to give 'em a good kick they're gone, the devil knows where. They're only an aggravation. You never kin do nothin' with 'em, and they kin do nothin' with you. I never kin understand why God Almighty wasted his time in makin' cavalry of any kind, Yank or rebel. All our own cavalry's good for is to steal whisky and chickens from honest soldiers of the infantry. The infantry's the only thing. It's like the big dog that comes up without any special remarks, and sets his teeth in the other dog. The thing only ends when one dog or the other is badly whipped and somethin's bin accomplished." "Mmm." Reuben started out of the half-waking state into which he had fallen. It was late in the afternoon, the sunlight had gone, and a wintry twilight crept up the wall. Maude the dairy-woman was looking in at the door. It was about a month subsequent to this, that one morning, as Turner was making the anvil ring with the ponderous strokes of his hammer, two retainers from the castle entered the shed, and delivered an order from De Boteler for his immediate attendance. Wat laid the hammer on the anvil, and, passing the back of his right hand across his forehead, to clear away the large drops that stood there, looked with a kind of smile at the men as he said, HoME泷泽萝拉四部和集下载
ENTER NUMBET 0016hcdram.com.cn etxyse.com.cn www.ejpo.com.cn www.jwchain.com.cn www.robchef.com.cn shanglaowu.com.cn www.slmelec.org.cn www.pnchain.com.cn www.nedoo.com.cn www.sptqyh.com.cn
